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Vardenafil


Vardenafil hydrochloride is a drug that is used to treat the issue of erectile dysfunction. The drug belongs to the class of medicines known as phosphodiesterase type 5 inhibitors. Due to its powerful mechanism, the drug is a renowned therapy for treating male impotence.

How does Vardenafil work?

Vardenafil provides the male organ, penis, the capability to remain erect and hard in order to perform various sexual activities. This action of vardenafil is quite physiological. Broadly, it allows a greater flow of blood into the male organ which results in a rocklike erection. The drug helps retaining the blood flow in the structure for a longer period.

Vardenafil has an action similar to that of sildenafil and tadalafil. The erection in a man’s organ takes place by the engorgement of the organ with a lot of blood. The engorgement is the result of blood vessels providing blood to the organ to become harder and erect straight. On the other hand, reversing of the blood flow decrease the supply and thus, the organ becomes flaccid.

Typical mechanism of Vardenafil (Pharmacokinetics)

Sexual stimulation that causes in erection of the male organ results the production and release of nitric oxide in the structure of the organ. The presence of nitric oxide further triggers and activates the enzyme called guanylate cyclase that further produces cyclic guanosine monophosphate (cGMP). The cGMP is the main factor to widen or constrict the blood vessels in the penis.

Vardenafil forbids the action of the enzyme known as phosphodiesterase -5 (PDE-5) from pacifying the action of cGMP and thus, as a result, cGMP’s action is prolonged. The longer the cGMP remains, the longer the erections stays on.

Important thing to note is though you are on the therapy of vardenafil, you still need to be sexually aroused. This is because, the drug requires initial set up of erection that happens physiologically. In any case, this drug will not have any effects if the consumer is not sexually stimulated. Depending upon your requirement, vardenafil dosage can be adjusted. You need to refer some guide or a healthcare provider in order to know the dosage.

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